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Cooling Agent

  • WS-12 Cooling Agent
WS-12 Cooling Agent

WS-12 Cooling Agent

  • CAS No.: 68489-09-8
  • Appearance: White crystal powder
  • Purity: ≥99%
  • FEMA: 4681
  • Description: Xi'an Taima professional manufacture high quality cooling agent WS-12.
  • Inquiry

What is Cooling Agent WS-12

Cooling Agent WS-12 powder is a potent TRPM8 agonist that acts as a cooling agent (EC50 = 193 nM). It robustly activated TRPM8 in low micromolar concentrations (EC50 12+/-5 microM) thereby displaying a higher potency and efficacy compared to menthol (EC50 196+/-22 microM). The selectivity profile of WS-12, its several-fold higher potency and around two-fold increase in efficacy compared to menthol warrants its potential utility for therapy in chronic neuropathic pain states and as a diagnostic probe in prostate cancer.

It is a menthol derivative. But unlike menthol, it is virtually nonvolatile, odorless and tasteless. It offers one of the strongest initial cooling impacts and a significantly longer lasting effect comparing with such conventional coolants such as WS-3, WS-5, and WS-23. It has potential for use in mint flavors in oral care applications as well as confectionary and chewing gum depending on dosage levels. In addition it can be used at low levels to impart freshness into berry, citrus and other fruit flavors in a variety of applications. WS-12 has been found to cool primarily at the front of the tongue.

Cooling Agent WS-12 Chemical & Physical Properties:

Product Name

WS-12 Cooling Agent

Chemical Name







White Crystalline solid


Slight menthol odor







Cooling Agent WS-12 Applications:

1.Daily use products: Toothpaste, oral products, Air Freshener, skin cream, shaving cream, shampoo, sunscreen, shower cream.

2.Food products: Confectionery products, chocolate, dairy produce, beer, distilled spirit, beverage,chewing Gum.

3.Medicine: Linctus, diminish inflammation ointment, dyspepsia, antipruritic, liniment, oral cavityacesodyne, heatstroke pill.

4.Others: Cigarette, filter tip and other tobacco, it also can be used for driving insects.

Cooling Agent WS-12 Usage:

1.Soluble in Ethanol/PG firstly, then adding water solution.
2.Or dissolved in flavors firstly, then added into your products.
3.Mixed with dementholized peppermint oil can increase the fragrance signally.

Cooling Agent WS-12 Certificate:

For other related certificates, please contact us.

Why Choose Xi’an Taima Cooling Agent WS-12 Powder?

Xi’an Taima has been a major supplier of the cooling compounds including WS-3, WS-5, WS-12, WS-23,WS-10,WS-27,Menthyl Acetate and L-Menthyl Lactate. These products allow our customers to use coolants in a broader array of market segments and applications. Xi’an Taima research demonstrates individual coolants are perceived in specific areas of the mouth with different cooling profiles. Each coolant provides unique characteristics in terms of cooling intensity and longevity, combined with negligible odor and low volatility.

Xi’an Taima specialize in Cooling Agent for several years, we supply product with competitive price, and our product is of the highest quality and undergoes strict, independent testing to ensure that it is safe for consumption around the world.


WS-12 is light sensitive, the solid material and any solutions obtained are protected from exposure to light.


Can customize the packaging: 500gram, 1kg and so non.

• 25Kg/Fiber Drum, double plastic bag inside, with carton outside.

• Sample – aluminum foil bag vacuum packing.

Contact Us

contact:Alina Shi

Tel:+86 15619038117



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